Metastaic Lung SarcomaHi brother has just been diagnisied with metastaic lung sarcoma 2 months after having his primary sarcoma removed from the abdomen. The tumors have appeared in both lungs. The right alot larger that the left the left has x2 small ones present. The doctors have told him he will need chemotherapy an d the secondary is aggressive and surgery is an option. what is the long term prognosis....
Thalidomide Plus Dexamethasone Effective In Newly Diagnosed Multiple MyelomaThalidomide plus dexamethasone therapy is effective in patients with newly diagnosed multiple myeloma. According to a recently published study from Mexico, "Multiple myeloma (MM) is a malignant plasma cell tumor that is distributed at multiple sites within the bone marrow compartments. "High-dose dexamethasone regimens [including vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy] induce rapid responses, and have resulted in improved survival for many patients when followed by intensive therapy with autologous stem cell support early in the disease course." "However," V.H. Jimenez-Zepeda and colleagues at the Mexico National Institute of Ciencias Medicas y Nutricion Salvador Zubiran in Mexico City said, "VAD have severa...
Mesothelioma Applied Research Foundation Names Nicholas J. Vogelzang, M.D. as New Board Chair: The Mesothelioma Applied Research Foundation (Meso Foundation), the national nonprofit dedicated to eradicating mesothelioma (meso) as a life-ending disease, announced today that illustrious cancer researcher, Nicholas J. Vogelzang, M.D., F.A.C.P., has become the new chair of the Foundation’s Board of Directors. Dr. Vogelzang is the director of Nevada Cancer Institute (NVCI) and formerly served as the [...]
Key To Lung Cancer Chemo Resistance FoundBALTIMORE -- U.S. scientists have discovered how a "detox" gene causes chemotherapy resistance in a common form of lung cancer. Johns Hopkins University researchers say products made by a gene called NRF2 normally protect cells from environmental pollutants such as cigarette smoke by absorbing the materials and pumping them from the cell. Another gene called KEAP1 encodes products that halt the cleansing process. But lung cancer cells sabotage the expression of these same genes to block assault from chemotherapy drugs. "What we're seeing is that lung cancer cells recruit and distort NRF2 and KEAP1 expression to help tumor cells evade the toxic effects of chemotherapy," said Associate Professor Shyam Biswal, who led the c...
Lung Cancer Progression May Be Revealed By Circulating Endocan LevelsLung cancer progression may be revealed by circulating endocan levels. According to a study from France, "We evaluated the expression of endocan, a soluble lung- and kidney-selective endothelial cell-specific dermatan sulfate proteoglycan, in non-small cell lung tumors compared with normal lung and studied the significance of high levels of circulating endocan in patients with non-small cell lung cancer. "Endocan and vascular endothelial growth factor mRNA expression were evaluated by semiquantitative polymerase chain reaction in tumoral and nontumoral lung tissue samples from a first series of 24 patients submitted to curative surgery. Relationships between survival, time to tumor progression, and serum levels of endocan were evaluat...
Exposure to Some Rock Powder Can Cause Malignant Mesothelioma Californians who live close to naturally occurring asbestos sources and who are exposed to low levels of the mineral are at increased risk for developing cancerous mesothelioma, a serious cancer of the membrane covering the lung, according to a new study published in the second issue of the October 2005 American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. Marc B. Schenker, M.D., M.P.H., of the Division of Environmental and Occupational Health, at the University of California, Davis, along with four associates, investigated 2,908 cancerous mesothelioma cases reported over a 10-year period (1988 to 1997). Over 50 percent of the men and 58 percent of the women, all of whom were listed in the California Canc......
